| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Cranberry | 📋 | ✍ | ⛔ | | 38651941 | Cranberry Polyphenols and Prevention against Urinary Tract Infections: New Findings Related to the Integrity and Functionality of Intestinal and Urinary Barriers |
| Curcumin | 📋 | ✍ | ⛔ | | 38273747 | Curcumin Inhibits Bladder Cancer by Inhibiting Invasion via AKT/MMP14 Pathway |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38357327 | Potential role for vitamin D vs. intermittent fasting in controlling aquaporin-1 and aquaporin-3 expression in HFD-induced urinary bladder alterations in rats |
| Sulforaphane | 📋 | ✍ | ⛔ | | 38474751 | Sulforaphane Inhibits Adhesion and Migration of Cisplatin- and Gemcitabine-Resistant Bladder Cancer Cells In Vitro |
| D-Mannose | 📋 | ✍ | ⛔ | | 38101412 | D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder |
| Melatonin | 📋 | ✍ | ⛔ | | 38478501 | Melatonin serves as a novel treatment in bladder fibrosis through TGF-β1/Smad and EMT |
| Cannabidiol | 📋 | ✍ | ⛔ | | 36902479 | Cannabidiol as a Promising Therapeutic Option in IC/BPS: In Vitro Evaluation of Its Protective Effects against Inflammation and Oxidative Stress |
| Chondroitin | 📋 | ✍ | ⛔ | | 38721680 | Oral preparation of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C improves sexual and urinary symptoms in participants with recurrent urinary tract infections: a randomized crossover trial |
| Saw Palmetto | 📋 | ✍ | ⛔ | | 34672430 | Effects of saw palmetto extract on the vanilloid receptor TRPV1 |
| Bee Propolis | 📋 | ✍ | ⛔ | | 37905787 | Propolis as an adjunctive therapy for treatment of uncomplicated cystitis in women: A randomized double-blind placebo-controlled trial |
| EGCG | 📋 | ✍ | ⛔ | | 38084438 | G3BP1 and SLU7 Jointly Promote Immune Evasion by Downregulating MHC-I via PI3K/Akt Activation in Bladder Cancer |
| Vitamin C | 📋 | ✍ | ⛔ | | 38721680 | Oral preparation of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C improves sexual and urinary symptoms in participants with recurrent urinary tract infections: a randomized crossover trial |
| Quercetin | 📋 | ✍ | ⛔ | | 38526326 | Identification of key pathways and mRNAs in interstitial cystitis/bladder pain syndrome treatment with quercetin through bioinformatics analysis of mRNA-sequence data |
| Roselle | 📋 | ✍ | ⛔ | | 35052890 | Xyloglucan, Hibiscus and Propolis in the Management of Uncomplicated Lower Urinary Tract Infections: A Systematic Review and Meta-Analysis |
| Hyaluronic Acid | 📋 | ✍ | ⛔ | | 38721680 | Oral preparation of hyaluronic acid, chondroitin sulfate, N-acetylglucosamine, and vitamin C improves sexual and urinary symptoms in participants with recurrent urinary tract infections: a randomized crossover trial |
| Licochalcones | 📋 | | | | 31387245 | Anti-Proliferative and Pro-Apoptotic Effects of Licochalcone A through ROS-Mediated Cell Cycle Arrest and Apoptosis in Human Bladder Cancer Cells |
| Metformin | 📋 | ✍ | ⛔ | | 36455340 | Synergistic effect of metformin and doxorubicin on the metastatic potential of T24 cells |
| Resveratrol | 📋 | ✍ | ⛔ | | 36901993 | Focus on the Use of Resveratrol in Bladder Cancer |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 34075841 | A prospective observational study on oral administration of Ellagic Acid and Annona Muricata in patients affected by non-muscle invasive bladder cancer not undergoing maintenance after 6-week intravesical prophylaxis |
| Frankincense | 📋 | ✍ | ⛔ | | 36442480 | Efficacy of frankincense-based herbal product in urinary incontinence: A randomized, double-blind, placebo- and active-controlled clinical trial |
| Genistein | 📋 | ✍ | ⛔ | | 33396024 | HER2 overexpression triggers the IL-8 to promote arsenic-induced EMT and stem cell-like phenotypes in human bladder epithelial cells |
| Puerarin | 📋 | ✍ | ⛔ | | 35962806 | Puerarin protects fibroblasts against mechanical stretching injury through Nrf2/TGF-β1 signaling pathway |
| Silibinin | 📋 | ✍ | | | 38164275 | Role of heat shock protein 70 in silibinin-induced apoptosis in bladder cancer |
| Apigenin | 📋 | ✍ | ⛔ | | 37375759 | Spasmolytic and Uroprotective Effects of Apigenin by Downregulation of TGF-β and iNOS Pathways and Upregulation of Antioxidant Mechanisms: In Vitro and In Silico Analysis |
| Berberine | 📋 | ✍ | ⛔ | | 37955270 | Uroprotective effects of berberine and curcumin in cyclophosphamide-induced interstitial cystitis |
| Daidzein | 📋 | ✍ | ⛔ | | 36267287 | Daidzein is the in vivo active compound of Puerariae Lobatae Radix water extract for muscarinic receptor-3 inhibition against overactive bladder |
| Fucoidan | 📋 | ✍ | ⛔ | | 36099992 | Fucoidan from Sargassum hemiphyllum inhibits the stemness of cancer stem cells and epithelial-mesenchymal transitions in bladder cancer cells |
| Chrysin | 📋 | ✍ | ⛔ | | 37263553 | Uro-protective role of chrysin against cyclophosphamide-induced hemorrhagic cystitis in rats involving the turning-off NF-κB/P38-MAPK, NO/PARP-1 and STAT-3 signaling cascades |
| Cinnamaldehyde | 📋 | | | | 34976095 | Suppression of Inflammatory and Fibrotic Signals by Cinnamon ( Cinnamomum cassia) and Cinnamaldehyde in Cyclophosphamide-Induced Overactive Bladder in Mice |
| Cinnamon | 📋 | ✍ | ⛔ | | 35990198 | Antitumor Activities of Aqueous Cinnamon Extract on 5637 Cell Line of Bladder Cancer through Glycolytic Pathway |
| Luteolin | 📋 | ✍ | ⛔ | | 34804174 | Luteolin Improves Cyclophosphamide-Induced Cystitis through TXNIP/NLRP3 and NF- κ B Pathways |
| Magnesium | 📋 | ✍ | ⛔ | | 35153759 | Magnesium-Assisted Cisplatin Inhibits Bladder Cancer Cell Survival by Modulating Wnt/β-Catenin Signaling Pathway |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 37630763 | Novel Key Ingredients in Urinary Tract Health-The Role of D-mannose, Chondroitin Sulphate, Hyaluronic Acid, and N-acetylcysteine in Urinary Tract Infections (Uroial PLUS®) |
| Pomegranate | 📋 | | ⛔ | | 33895929 | Punica granatum Extract Inhibits Bladder Cancer Cell Viability, Invasion and Migration through Down-Regulation of HOXD10 Signalling Pathway |
| Thymoquinone | 📋 | | ⛔ | | 37219672 | Thymoquinone enhanced the antitumor activity of cisplatin in human bladder cancer 5637 cells in vitro |
| Vitamin A | 📋 | ✍ | ⛔ | | 35215508 | Are We Sentenced to Pharmacotherapy? Promising Role of Lycopene and Vitamin A in Benign Urologic Conditions |
| Astragalus Root | 📋 | ✍ | ⛔ | | 37733667 | Astragalus polysaccharide inhibits the development of urothelial carcinoma by activating AMPK signaling to induce BENC1-xCT complex formation |
| Betulinic Acid | 📋 | | | | 34510030 | Betulinic acid induces autophagy-dependent apoptosis via Bmi-1/ROS/AMPK-mTOR-ULK1 axis in human bladder cancer cells |
| Capsaicin | 📋 | ✍ | ⛔ | | 36334234 | Dietary Capsaicin Reduces Chemically Induced Rat Urinary Bladder Carcinogenesis |
| Cat's Claw | 📋 | ✍ | ⛔ | | 26154141 | The Quinovic Acid Glycosides Purified Fraction from Uncaria tomentosa Protects against Hemorrhagic Cystitis Induced by Cyclophosphamide in Mice |
| Conjugated Linoleic Acid | 📋 | ✍ | ⛔ | | 36545457 | Effect of Conjugated Linoleic Acid (CLA) Supplementation on Expression of B-Cell Lymphoma-2 (Bcl-2) in the Bladder Epithelium of Wistar (Rattus norvegicus) Rats Exposed to Cigarette Smoke |
| Gallic Acid | 📋 | | ⛔ | | 38184176 | Evaluation of antibacterial, antifungal and antibiofilm activities of A. baumannii-derived tannase and gallic acid against uropathogenic microorganisms |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 27467005 | Induction of Cell Cycle Arrest and Apoptosis by Grape Seed Procyanidin Extract in Human Bladder Cancer BIU87 Cells |
| Honokiol | 📋 | | | | 34392643 | Mechanism of apoptotic induction on T24 cells by honokiol and its synergistic anticancer effect in combination with hydroxycamptothecin |
| L-Arginine | 📋 | ✍ | ⛔ | | 9915448 | A Randomized Double-Blind Trial of Oral L-arginine for Treatment of Interstitial Cystitis |
| L-Methionine | 📋 | ✍ | ⛔ | | 32403906 | Efficacy of Food Supplement Acidif Plus® in the Treatment of Uncomplicated UTIs in Women: A Pilot Observational Study |
| Magnolol | 📋 | | | | 37549536 | Unveiling nature's potential weapon: Magnolol's role in combating bladder cancer by upregulating the miR-124 and inactivating PKC-δ/ERK axis |
| Nobiletin | 📋 | ✍ | | | 37109094 | Effectiveness and Safety of a Mixture of Nobiletin and Tangeretin in Nocturia Patients: A Randomized, Placebo-Controlled, Double-Blind, Crossover Study |
| Phytochemicals | 📋 | | | | 35800376 | Natural bioactive compounds: a potential therapeutic strategy to sensitize bladder cancer to cisplatin treatment? |
| Pine Bark | 📋 | ✍ | ⛔ | | 34738775 | Pycnogenol® supplementation prevents inflammation and symptoms in recurrent, non-severe urinary infections |
| Probiotics | 📋 | ✍ | ⛔ | | 35507743 | Effect of probiotics on urinary tract infections in children: A systematic review and meta-analysis |
| Pumpkin Seed Oil | 📋 | ✍ | ⛔ | | 31261419 | Cucurbita pepo-Rhus aromatica-Humulus lupulus Combination Reduces Overactive Bladder Symptoms in Women - A Noninterventional Study |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 28484937 | Effects of Ganoderma Lucidum shell-broken spore on oxidative stress of the rabbit urinary bladder using an in vivo model of ischemia/reperfusion |
| Retinoic Acid | 📋 | | | | 38539513 | The Effect of Retinoic Acid on Arsenite-Transformed Malignant UROtsa Bladder Cancer Cells: In Vitro Model of Basal Muscle-Invasive Bladder Cancer |
| Amygdalin | 📋 | ✍ | ⛔ | | 25333694 | Amygdalin influences bladder cancer cell adhesion and invasion in vitro |
| Astragalosides | 📋 | ✍ | ⛔ | | 35873803 | Astragaloside IV Protects Detrusor from Partial Bladder Outlet Obstruction-Induced Oxidative Stress by Activating Mitophagy through AMPK-ULK1 Pathway |
| Balloon Flower | 📋 | ✍ | ⛔ | | 35938960 | Induction of apoptosis through inactivation of ROS-dependent PI3K/Akt signaling pathway by platycodin D in human bladder urothelial carcinoma cells |
| Biochanin A | 📋 | | | | 10656454 | The Potential of Soybean Foods as a Chemoprevention Approach for Human Urinary Tract Cancer |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 35559194 | Boswellic Acids, Pentacyclic Triterpenes, Attenuate Oxidative Stress, and Bladder Tissue Damage in Cyclophosphamide-Induced Cystitis |
| CAPE | 📋 | | | | 35884930 | The Upregulation of Caffeic Acid Phenethyl Ester on Growth Differentiation Factor 15 Inhibits Transforming Growth Factor β/Smad Signaling in Bladder Carcinoma Cells |
| Carotenoids | 📋 | ✍ | ⛔ | | 31800007 | Carotenoid Intake and Circulating Carotenoids Are Inversely Associated with the Risk of Bladder Cancer: A Dose-Response Meta-analysis |
| Clove | 📋 | | ⛔ | | 34367514 | Antioxidant-rich Clove Extract, A Strong Antimicrobial Agent against Urinary Tract Infections-causing Bacteria in vitro |
| Emodin | 📋 | | ⛔ | | 38504574 | The Role of Emodin in the Treatment of Bladder Cancer based on Network Pharmacology and Experimental Verification |
| Fisetin | 📋 | ✍ | ⛔ | | 34836005 | Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature |
| Folate | 📋 | ✍ | ⛔ | | 34472414 | Folate Intake and Risk of Urothelial Carcinoma: A Systematic Review and Meta-Analysis of Epidemiological Studies |
| Formononetin | 📋 | | | | 37288590 | Comparative transcriptomic analysis and mechanistic characterization revealed the use of formononetin for bladder cancer treatment |
| Frankincense Essential Oil | 📋 | | ⛔ | | 25006348 | Differential effects of selective frankincense (Ru Xiang) essential oil versus non-selective sandalwood (Tan Xiang) essential oil on cultured bladder cancer cells: a microarray and bioinformatics study |
| Ginsenosides | 📋 | ✍ | ⛔ | | 25175462 | Synergistic antitumor effect of ginsenoside Rg3 and cisplatin in cisplatin‑resistant bladder tumor cell line |
| Hesperetin | 📋 | | | | 38357946 | Hesperetin Inhibits Bladder Cancer Cell Proliferation and Promotes Apoptosis and Cycle Arrest by PI3K/AKT/FoxO3a and ER Stress-mitochondria Pathways |
| Inulin | 📋 | ✍ | ⛔ | | 34251095 | [Antiadhesive strategy for non-antibacterial prophylaxis of recurrent lower urinary tract infections] |
| Isoflavones | 📋 | ✍ | ⛔ | | 30903485 | Flavonoids and Bladder Cancer Risk |
| Isorhamnetin | 📋 | | | | 36905861 | Effect of isorhamnetin on carbonic anhydrase IX expression and tumorigenesis of bladder cancer by activating PPARγ/PTEN/AKT pathway |
| Kaempferol | 📋 | ✍ | ⛔ | | 34836005 | Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature |
| L-Theanine | 📋 | ✍ | ⛔ | | 34822436 | l-Theanine Protects Bladder Function by Suppressing Chronic Sympathetic Hyperactivity in Spontaneously Hypertensive Rat |
| Lemon | 📋 | | ⛔ | | 37799616 | Antibacterial Activity of Selected Fruit Juices against Multidrug-Resistant Bacterial Pathogens Involved in Urinary Tract and Sexually Transmitted Infections among Tribal Women in Madhya Pradesh, India |
| Medicinal Plants | 📋 | | | | 38532487 | Medicinal plants and natural products for treating overactive bladder |
| Myrrh | 📋 | ✍ | ⛔ | | 32279153 | Efficacy of Frankincense and Myrrha in Treatment of Acute Interstitial Cystitis/Painful Bladder Syndrome |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 35467177 | Omega-3 polyunsaturated fatty acids: a modified approach for chemo-prevention of bladder cancer in a rat model and molecular studies of antineoplastic mechanisms |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 36362994 | Uncovering the Inhibitory Molecular Mechanism of Pomegranate Peel to Urinary Bladder Urothelial Carcinoma Using Proteomics Techniques |
| Pterostilbene | 📋 | ✍ | ⛔ | | 33036162 | Pterostilbene Sensitizes Cisplatin-Resistant Human Bladder Cancer Cells with Oncogenic HRAS |
| Pumpkin Seed | 📋 | ✍ | ⛔ | | 35176933 | Outcomes of a complementary and alternative medicine based on vitamins, herbal products, and amino acid as a first line treatment in idiopathic overactive bladder syndrome in men and women without bladder outlet obstruction |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 19462485 | Dietary Soy Isoflavone Replacement Improves Detrusor Overactivity of Ovariectomized Rats With Altered connexin-43 Expression in the Urinary Bladder |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 24938176 | Fixed-dose combination PRO 160/120 of sabal and urtica extracts improves nocturia in men with LUTS suggestive of BPH: re-evaluation of four controlled clinical studies |
| Tangeretin | 📋 | | | | 37109094 | Effectiveness and Safety of a Mixture of Nobiletin and Tangeretin in Nocturia Patients: A Randomized, Placebo-Controlled, Double-Blind, Crossover Study |
| Thyme Essential Oil | 📋 | | ⛔ | | 34833945 | The Impact of Selected Essential Oils Applied to Non-Woven Viscose on Bacteria That Cause Lower Urinary Tract Infections-Preliminary Studies |
| Thymol | 📋 | ✍ | ⛔ | | 37481428 | Effect of thymol on antimicrobial susceptibility, and adhesion genes expression of uropathogenic Escherichia coli isolated from pediatric urinary tract infection |
| Urolithins | 📋 | | | | 28631098 | Urolithins impair cell proliferation, arrest the cell cycle and induce apoptosis in UMUC3 bladder cancer cells |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 32382009 | Vitamin K2 Promotes PI3K/AKT/HIF-1α-mediated Glycolysis That Leads to AMPK-dependent Autophagic Cell Death in Bladder Cancer Cells |
| Acai Berry | 📋 | ✍ | ⛔ | | 22961050 | Inhibition of mouse urinary bladder carcinogenesis by açai fruit (Euterpe oleraceae Martius) intake |
| Allicin | 📋 | ✍ | ⛔ | | 35246671 | Allicin suppressed Escherichia coli-induced urinary tract infections by a novel MALT1/NF-κB pathway |
| Andrographolide | 📋 | | | | 30745855 | Andrographolide Enhances TRAIL-Induced Apoptosis via p53-Mediated Death Receptors Up-Regulation and Suppression of the NF-кB Pathway in Bladder Cancer Cells |
| Angelica | 📋 | ✍ | ⛔ | | 29207978 | Potential therapeutic effects of N-butylidenephthalide from Radix Angelica Sinensis (Danggui) in human bladder cancer cells |
| Anthocyanins | 📋 | ✍ | ⛔ | | 29749527 | Purple Sweet Potato Anthocyanin Exerts Antitumor Effect in Bladder Cancer |
| Arctigenin | 📋 | | | | 22619087 | Arctigenin anti-tumor activity in bladder cancer T24 cell line through induction of cell-cycle arrest and apoptosis |
| Bacopa Monnieri | 📋 | ✍ | ⛔ | | 35956923 | Antibacterial Potential of Bacopa monnieri (L.) Wettst. and Its Bioactive Molecules against Uropathogens-An In Silico Study to Identify Potential Lead Molecule(s) for the Development of New Drugs to Treat Urinary Tract Infections |
| Baicalein | 📋 | ✍ | ⛔ | | 27571890 | Baicalein Induces Apoptosis via ROS-dependent Activation of Caspases in Human Bladder Cancer 5637 Cells |
| Baicalin | 📋 | ✍ | ⛔ | | 35024325 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1 |
| Barberry | 📋 | ✍ | ⛔ | | 33520087 | Berbamine Suppresses the Progression of Bladder Cancer by Modulating the ROS/NF- κ B Axis |
| Beta-Lapachone | 📋 | | | | 16614704 | beta-lapachone induces growth inhibition and apoptosis in bladder cancer cells by modulation of Bcl-2 family and activation of caspases |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 38273755 | β-Sitosterol Alleviates the Proliferation and Migration of Cystitis Glandularis-Associated Cells by Targeting HMGCR to Induce NLRP3-Dependent Pyroptosis |
| Blueberry | 📋 | ✍ | ⛔ | | 32369959 | Blueberry Prevents the Bladder Dysfunction in Bladder Outlet Obstruction Rats by Attenuating Oxidative Stress and Suppressing Bladder Remodeling |
| Burdock | 📋 | | ⛔ | | 25226848 | Burdock root extracts limit quorum-sensing-controlled phenotypes and biofilm architecture in major urinary tract pathogens |
| Carrot | 📋 | | ⛔ | | 29100438 | Carrot intake and incidence of urothelial cancer: a systematic review and meta-analysis |
| Catechins | 📋 | | | | 15331156 | Catechins prevents substance P-induced hyperactive bladder in rats via the downregulation of ICAM and ROS |
| Celery | 📋 | | ⛔ | | 35341158 | Cytoprotective Antioxidant, Anti-Inflammatory, and Antifibrotic Impact of Celery Seed Oil and Manuka Honey Against Cyclophosphamide-Induced Cystitis in Rabbits |
| Chaga Mushrooms | 📋 | ✍ | ⛔ | | 37153767 | Anti-cancer activity of Chaga mushroom ( Inonotus obliquus) against dog bladder cancer organoids |
| Chamomile Essential Oil | 📋 | ✍ | ⛔ | | 34833945 | The Impact of Selected Essential Oils Applied to Non-Woven Viscose on Bacteria That Cause Lower Urinary Tract Infections-Preliminary Studies |
| Chili Pepper | 📋 | | ⛔ | | 35176933 | Outcomes of a complementary and alternative medicine based on vitamins, herbal products, and amino acid as a first line treatment in idiopathic overactive bladder syndrome in men and women without bladder outlet obstruction |
| Chokeberry | 📋 | ✍ | ⛔ | | 25026919 | Black Chokeberry Juice (Aronia Melanocarpa) Reduces Incidences of Urinary Tract Infection Among Nursing Home Residents in the Long Term--A Pilot Study |
| Choline | 📋 | ✍ | ⛔ | | 38334759 | Effect of Dietary Choline Consumption on the Development of Urinary Urgency Incontinence in a Longitudinal Cohort of Women |
| Coconut Oil | 📋 | | ⛔ | | 36249458 | Coconut oil rubbing as an easy and safe way to improve symptoms in primary nocturnal enuresis: A randomized double-blinded placebo-controlled clinical trial |
| Copper | 📋 | ✍ | ⛔ | | 36869998 | Association Between Serum Copper Levels and Urinary Incontinence in Adult Men |
| Coptis Chinensis | 📋 | | ⛔ | | 35095505 | Dissecting and Evaluating the Therapeutic Targets of Coptis Chinensis Franch in the Treatment of Urinary Tract Infections Induced by Escherichia coli |
| CoQ10 | 📋 | ✍ | ⛔ | | 31660941 | CoQ10 Ameliorates Monosodium Glutamate-Induced Alteration in Detrusor Activity and Responsiveness in Rats via Anti-Inflammatory, Anti-Oxidant and Channel Inhibiting Mechanisms |
| Crocetin | 📋 | | | | 34792197 | Crocetin attenuating Urinary tract Infection and adherence of uropathogenic E. coli in NRK-52E cells via an inflammatory pathway |
| Cryptotanshinone | 📋 | | | | 31897244 | Cryptotanshinone Inhibites Bladder Cancer Cell Proliferation and Promotes Apoptosis via the PTEN/PI3K/AKT Pathway |
| Dandelion | 📋 | ✍ | ⛔ | | 34979364 | Rational development and evaluation of novel formulations for urinary health |
| Diallyl Trisulfide | 📋 | | | | 33730908 | Diallyl trisulfide inhibited tobacco smoke-mediated bladder EMT and cancer stem cell marker expression via the NF-κB pathway in vivo |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 22241170 | Ampelopsin sodium exhibits antitumor effects against bladder carcinoma in orthotopic xenograft models |
| Dihydroquercetin | 📋 | | | | 35613889 | Effect of taxifolin on cyclophosphamide-induced oxidative and inflammatory bladder injury in rats |
| DIM | 📋 | ✍ | ⛔ | | 35283486 | Androgen receptor modulation and bladder cancer prevention - a short review |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 32756427 | Docosahexaenoic Acid Reverted the All- trans Retinoic Acid-Induced Cellular Proliferation of T24 Bladder Cancer Cell Line |
| Echinacea | 📋 | ✍ | ⛔ | | 2073038 | [Determination of the Activity of Extracts of Echinaceae and Sabal in the Treatment of Idiopathic Megabladder in Women] |
| Echinacoside | 📋 | | | | 35758826 | Echinacoside Ameliorates Cyclophosphamide-Induced Bladder Damage in Mice |
| Equol | 📋 | ✍ | ⛔ | | 19903517 | Comparison of Urodynamic Effects of Phytoestrogens Equol, Puerarin and Genistein With These of Estradiol 17beta in Ovariectomized Rats |
| Escin | 📋 | ✍ | ⛔ | | 30287153 | Escin induces apoptosis in human bladder cancer cells: An in vitro and in vivo study |
| Fish | 📋 | | ⛔ | | 36411185 | Fatty foods and the risk of bladder cancer: A case-control study |
| Flavones | 📋 | | | | 30903485 | Flavonoids and Bladder Cancer Risk |
| Flavonoids | 📋 | | ⛔ | | 36185766 | Properties of flavonoids in the treatment of bladder cancer (Review) |
| Flaxseed | 📋 | ✍ | ⛔ | | 30963048 | Clinical study of effectiveness and safety of CELcomplex ® containing Cucurbita Pepo Seed extract and Flax and Casuarina on stress urinary incontinence in women |
| Food | 📋 | | | | 36274962 | Low-fat dietary pattern reduces urinary incontinence in postmenopausal women: post hoc analysis of the Women's Health Initiative Diet Modification Trial |
| Fruits | 📋 | | | | 35334790 | Clinical Potential of Fruit in Bladder Cancer Prevention and Treatment |
| Galangal | 📋 | ✍ | ⛔ | | 37976696 | Multi-omic analysis revealed the therapeutic mechanisms of Alpinia oxyphylla fructus water extract against bladder overactivity in spontaneously hypertensive rats |
| Galangin | 📋 | | | | 36305128 | Network-based pharmacology and in vitro validation reveal that galangin induces apoptosis in bladder cancer cells by promoting the p53 signaling pathway |
| Gingerol | 📋 | ✍ | | | 35919815 | [6]-Gingerol induces Caspase-Dependent Apoptosis in Bladder Cancer cells via MAPK and ROS Signaling |
| Ginkgolides | 📋 | | | | 27744452 | Ginkgolide B Inhibits Human Bladder Cancer Cell Migration and Invasion Through MicroRNA-223-3p |
| Ginseng | 📋 | ✍ | ⛔ | | 35856363 | Analysis of ginseng in the treatment of Interstitial Cystitis/Bladder Pain Syndrome based on network pharmacology |
| Glabridin | 📋 | | | | 36098706 | Glabridin inhibits urothelial bladder carcinoma cell growth in vitro and in vivo by inducing cell apoptosis and cell cycle arrest |
| Glucosamine | 📋 | ✍ | ⛔ | | 19046494 | Treatment of Refractory Interstitial Cystitis/Painful Bladder Syndrome With CystoProtek--an Oral Multi-Agent Natural Supplement |
| Goji Berry | 📋 | ✍ | ⛔ | | 27992374 | Lycium Barbarum Polysaccharides Inhibit Proliferation and Migration of Bladder Cancer Cell Lines BIU87 by Suppressing Pi3K/AKT Pathway |
| Grape | 📋 | | ⛔ | | 15742347 | Protection of urinary bladder function by grape suspension |
| Grapefruit extract | 📋 | ✍ | ⛔ | | 15865506 | The effectiveness of grapefruit (Citrus paradisi) seeds in treating urinary tract infections |
| Graviola | 📋 | ✍ | ⛔ | | 34075841 | A prospective observational study on oral administration of Ellagic Acid and Annona Muricata in patients affected by non-muscle invasive bladder cancer not undergoing maintenance after 6-week intravesical prophylaxis |
| Guggulsterone | 📋 | | | | 34044254 | Guggulsterone induces apoptosis and inhibits lysosomal-dependent migration in human bladder cancer cells |
| Hesperidin | 📋 | ✍ | ⛔ | | 14626685 | [Use of flavonoids (hesperidin) in the treatment of bleeding bladder varices] |
| Honey | 📋 | ✍ | ⛔ | | 35341158 | Cytoprotective Antioxidant, Anti-Inflammatory, and Antifibrotic Impact of Celery Seed Oil and Manuka Honey Against Cyclophosphamide-Induced Cystitis in Rabbits |
| Hops | 📋 | ✍ | ⛔ | | 31261419 | Cucurbita pepo-Rhus aromatica-Humulus lupulus Combination Reduces Overactive Bladder Symptoms in Women - A Noninterventional Study |
| Horsetail Grass | 📋 | ✍ | ⛔ | | 30963048 | Clinical study of effectiveness and safety of CELcomplex ® containing Cucurbita Pepo Seed extract and Flax and Casuarina on stress urinary incontinence in women |
| Hyperoside | 📋 | | | | 38464829 | Hyperoside induces cell cycle arrest and suppresses tumorigenesis in bladder cancer through the interaction of EGFR-Ras and Fas signaling pathways |
| Icariin | 📋 | ✍ | | | 35149295 | Icariin attenuates cyclophosphamide-induced cystitis via down-regulation of NF-кB and up-regulation of Nrf-2/HO-1 signaling pathways in mice model |
| Kacip Fatimah | 📋 | ✍ | ⛔ | | 21524700 | Labisia pumila var. alata reduces bacterial load by inducing uroepithelial cell apoptosis |
| Knotweed | 📋 | ✍ | ⛔ | | 35176933 | Outcomes of a complementary and alternative medicine based on vitamins, herbal products, and amino acid as a first line treatment in idiopathic overactive bladder syndrome in men and women without bladder outlet obstruction |
| Krill Oil | 📋 | ✍ | ⛔ | | 35651016 | In vitro and in vivo anti-tumor efficacy of krill oil against bladder cancer: Involvement of tumor-associated angiogenic vasculature |
| L-Carnitine | 📋 | ✍ | ⛔ | | 33148156 | Evaluation of Serum Level of Carnitine in Children with Acute Pyelonephritis (APN) Compared to Healthy Children |
| L-Glutamine | 📋 | ✍ | ⛔ | | 35176933 | Outcomes of a complementary and alternative medicine based on vitamins, herbal products, and amino acid as a first line treatment in idiopathic overactive bladder syndrome in men and women without bladder outlet obstruction |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 33287590 | Carcinogenesis and Bacillus Calmette-Guérin (BCG) Intravesical Treatment of Non-Muscle-Invasive Bladder Cancer under Tryptophan and Thymine Supplementation |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 35490236 | Anti-inflammatory effects of lavender and eucalyptus essential oils on the in vitro cell culture model of bladder pain syndrome using T24 cells |
| Licorice Root | 📋 | ✍ | ⛔ | | 37692489 | Echinatin inhibits tumor growth and synergizes with chemotherapeutic agents against human bladder cancer cells by activating p38 and suppressing Wnt/β-catenin pathways |
| Ligustilide | 📋 | | | | 36751909 | Ligustilide Induces Apoptosis and Reduces Proliferation in Human Bladder Cancer Cells by NFκB1 and Mitochondria Pathway |
| Lycopene | 📋 | ✍ | ⛔ | | 35215508 | Are We Sentenced to Pharmacotherapy? Promising Role of Lycopene and Vitamin A in Benign Urologic Conditions |
| Magnolia | 📋 | ✍ | ⛔ | | 17671727 | Aqueous extract of Magnolia officinalis mediates proliferative capacity, p21WAF1 expression and TNF-alpha-induced NF-kappaB activity in human urinary bladder cancer 5637 cells; involvement of p38 MAP kinase |
| Maitake Mushrooms | 📋 | | ⛔ | | 19735256 | Synergistic potentiation of interferon activity with maitake mushroom d-fraction on bladder cancer cells |
| Micronutrients | 📋 | | ⛔ | | 37108218 | Emerging Non-Antibiotic Options Targeting Uropathogenic Mechanisms for Recurrent Uncomplicated Urinary Tract Infection |
| Modified Citrus Pectin | 📋 | ✍ | ⛔ | | 29769742 | Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3 |
| MSM | 📋 | ✍ | ⛔ | | 24402583 | Combination of AG490, a Jak2 inhibitor, and methylsulfonylmethane synergistically suppresses bladder tumor growth via the Jak2/STAT3 pathway |
| Mulberry | 📋 | | ⛔ | | 26838546 | Promotion of mitotic catastrophe via activation of PTEN by paclitaxel with supplement of mulberry water extract in bladder cancer cells |
| Myricetin | 📋 | | ⛔ | | 34836005 | Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 36640148 | Effect of Nigella sativa L. seed oil on urinary incontinence and quality of life in menopausal women: A triple-blind randomized controlled trial |
| Nimbolide | 📋 | | | | 31391858 | Nimbolide Represses the Proliferation, Migration, and Invasion of Bladder Carcinoma Cells via Chk2-Mediated G2/M Phase Cell Cycle Arrest, Altered Signaling Pathways, and Reduced Transcription Factors-Associated MMP-9 Expression |
| Nuciferine | 📋 | | | | 36535262 | Role of Protopine and Nuciferine in the management of nocturia, urgency and dysuria in pre- and post-menopausal women: a prospective pilot study |
| Nutmeg | 📋 | ✍ | ⛔ | | 30519527 | Efficacy of mace (Arils of Myristica fragrans Houtt) plus PFMT on symptoms in mixed urinary incontinence: a randomized placebo-controlled trial |
| Nuts | 📋 | | ⛔ | | 36411185 | Fatty foods and the risk of bladder cancer: A case-control study |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 33100948 | Prevention and treatment of cystitis during menopause: efficacy of a nutraceutical containing D-mannose, inulin, cranberry, bearberry, Olea europaea, Orthosiphon and Lactobacillus acidophilus |
| Paeonol | 📋 | | | | 32691366 | Paeonol inhibits proliferation and induces cell apoptosis of human T24 and 5637 bladder cancer cells in vitro and in vivo |
| Piperlongumine | 📋 | | | | 35466450 | Piperlongumine increases the sensitivity of bladder cancer to cisplatin by mitochondrial ROS |
| Polyphenols | 📋 | | | | 36834683 | Natural Polyphenols for Prevention and Treatment of Urinary Tract Infections |
| Potassium | 📋 | ✍ | ⛔ | | 15098215 | Nutrient composition of the diet and the development of overactive bladder: a longitudinal study in women |
| Procyanidins | 📋 | | ⛔ | | 27467005 | Induction of Cell Cycle Arrest and Apoptosis by Grape Seed Procyanidin Extract in Human Bladder Cancer BIU87 Cells |
| Progesterone | 📋 | ✍ | ⛔ | | 33739310 | Hormone therapy as a possible solution for postmenopausal women with nocturia: results of a pilot trial |
| Punicalagin | 📋 | ✍ | ⛔ | | 28168411 | Potential therapeutic role of punicalagin against mechanical-trauma-induced stress urinary incontinence via upregulation of Nrf2 and TGF-β1 signaling : Effect of punicalagin on mechanical trauma induced SUI |
| Rapamycin | 📋 | ✍ | | | 35783514 | Evaluation of a Dual PI3K/mTOR Inhibitor PF-04691502 against Bladder Cancer Cells |
| Rhodiola | 📋 | ✍ | ⛔ | | 37370698 | The Potent Anti-Tumor Effects of Rhodiola Drinking Are Associated with the Inhibition of the mTOR Pathway and Modification of Tumor Metabolism in the UPII-Mutant Ha-Ras Model |
| Rosmarinic Acid | 📋 | ✍ | | | 37463180 | Rosmarinic acid ameliorates HCl-induced cystitis in rats |
| Rutin | 📋 | ✍ | ⛔ | | 19046494 | Treatment of Refractory Interstitial Cystitis/Painful Bladder Syndrome With CystoProtek--an Oral Multi-Agent Natural Supplement |
| Salidroside | 📋 | | | | 21520297 | Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy |
| Sandalwood Essential Oil | 📋 | | ⛔ | | 25006348 | Differential effects of selective frankincense (Ru Xiang) essential oil versus non-selective sandalwood (Tan Xiang) essential oil on cultured bladder cancer cells: a microarray and bioinformatics study |
| Schisandrins | 📋 | | | | 35664354 | Deoxyschizandrin Inhibits the Proliferation, Migration, and Invasion of Bladder Cancer Cells through ALOX5 Regulating PI3K-AKT Signaling Pathway |
| Shilajit | 📋 | ✍ | ⛔ | | 34799663 | Mumio (Shilajit) as a potential chemotherapeutic for the urinary bladder cancer treatment |
| Shogaol | 📋 | | | | 38329001 | [6]-Shogaol Induces Apoptosis of Murine Bladder Cancer Cells |
| Skullcap | 📋 | ✍ | ⛔ | | 34149863 | Molecular Targets and Mechanisms of Scutellariae radix- Coptidis rhizoma Drug Pair for the Treatment of Ulcerative Colitis Based on Network Pharmacology and Molecular Docking |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 15245964 | Inhibitory Effect of the Antidepressant St. John's Wort (Hypericum Perforatum) on Rat Bladder Contractility in Vitro |
| Stevia | 📋 | ✍ | ⛔ | | 35820501 | High-throughput screening identifies stevioside as a potent agent to induce apoptosis in bladder cancer cells |
| Strawberry | 📋 | ✍ | ⛔ | | 30345090 | Determination of Antimicrobial Activity of Some Commercial Fruit (Apple, Papaya, Lemon and Strawberry) Against Bacteria Causing Urinary Tract Infection |
| Tannic Acid | 📋 | ✍ | ⛔ | | 35691981 | Tannic acid attenuate AKT phosphorylation to inhibit UMUC3 bladder cancer cell proliferation |
| Taurine | 📋 | ✍ | ⛔ | | 17287017 | Taurine Ameliorates Stress-Induced Degeneration of the Urinary Bladder |
| Tea | 📋 | | | | 35413574 | Tea consumption and risk of bladder cancer in the Bladder Cancer Epidemiology and Nutritional Determinants (BLEND) Study: Pooled analysis of 12 international cohort studies |
| Tea Tree Essential Oil | 📋 | | ⛔ | | 32630444 | Anti-Bacterial Effects of Essential Oils Against Uropathogenic Bacteria |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 30932202 | Therapeutic potential of medicinal plants for the management of urinary tract infection: A systematic review |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 38443785 | The potential mechanism of ursolic acid in the treatment of bladder cancer based on network pharmacology and molecular docking |
| Vegetables | 📋 | | | | 38408431 | Outcomes of a Dietary Intervention to Reduce Bladder Cancer Recurrence and Progression in Survivors of Non-Muscle-Invasive Bladder Cancer |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 37665042 | Folic acid supplementation rescues bladder injury in fetal rats with myelomeningocele |
| Withaferin A | 📋 | | | | 34209212 | Withaferin A Triggers Apoptosis and DNA Damage in Bladder Cancer J82 Cells through Oxidative Stress |
